We are fearless innovators united by a shared mission: To bring transformative therapies to people living with serious muscle diseases. We pursue our goals with passion, determination, agility and urgency, recognizing that countless lives are depending on our efforts. We are here to forever change lives. We know we will deliver.
Our core values
Delivering for patients
Our purpose
Transforming the futures of people living with serious muscle diseases.
Dyne family
Our commitment
Acting with inclusion, transparency, respect, honesty and unity.
One mission, no ego
Our vision
Driving boldly toward a shared mission, we’re stronger as one team.
Embrace accountability to ensure excellence in execution
Our pledge
We do what we say we are going to do. What we do and how we do it defines success at Dyne.
Fearless innovation
Our resolve
We push ourselves and one another to think bigger, act bolder, aim higher and to never fear failure.
We’re looking for colleagues who share this ethos to join the Dyne family. If you’re driven to deliver for people living with serious muscle diseases; if you put team and mission first; if you embrace bold ideas; if you are committed to accountability and transparency; if you have a drive to make a difference, we’d love to connect.
connectWhy we joined
What drew me to Dyne was the company’s commitment to developing revolutionary therapies that target muscle tissue with unprecedented precision. It’s a joy to lead a research team with such unwavering dedication to transforming the lives of people and families living with serious muscle diseases.
– Oxana Beskrovnaya
Dyne’s approach has great potential to address the underlying cause of many different neuromuscular diseases, and to develop transformative therapies that uniquely draw from the experience of people living with those diseases. I’m delighted to be part of the team furthering that important mission.
– Deb Feldman
I was interested in joining a company where the developed therapy doesn’t improve the quality of life incrementally but is truly life-changing for the patient – a therapy that targets the root cause of the disease, not just the symptoms. I wanted to work with a team that are experts in the field, dynamic, and patient-focused.
– Tim Weeden
Dyne is an opportunity to take cutting-edge nucleic acid-based therapeutics and use our understanding of human biology to overcome the next set of hurdles in precision medicine. The team being built at Dyne is perfectly positioned to develop novel therapeutics for rare diseases, and I am ecstatic to have the opportunity to be a part of it.
– Cody Desjardins
One of the most unique parts of working at Dyne is being able to connect directly with the families we hope to serve and learn about their experiences, which inspires us and fosters a united sense of purpose among the Dyne team.
– Lilian Yengi
Dyne offers the opportunity to impact people’s lives in life-changing ways while also being part of a team that is exceptional at what they do and who they are.
– Sean Spring
Competitive benefits
Dyne offers our employees a competitive and comprehensive benefits package, which we believe is an important part of supporting the health and well-being of our employees and their families. These include:
- Medical Insurance
- Dental Insurance
- Vision Insurance
- Short & Long Term Disability
- Life Insurance
- Health Reimbursement Account
- Flexible Spending Accounts
- Dependent Care Spending Account
- 401(k)
- Flexible vacation, paid holidays, including one-week year-end office closure
Interested in joining the Dyne team? See our open positions below. For more information or to apply, please contact us.
contactCompany Overview:
Dyne Therapeutics is building a leading muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. We are utilizing our proprietary FORCE™ platform to overcome the current limitations of muscle tissue delivery with modern oligonucleotide therapeutic candidates. Dyne is developing a broad portfolio of therapeutics for muscle diseases, including lead programs in myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit www.dyne-tx.com, and follow us on Twitter, LinkedIn and Facebook.
Role
Dyne is seeking an experienced attorney to join our Legal team as the individual responsible for preparing and negotiating agreements across the entire organization. This individual will have significant agreement experience in the biotech and pharmaceutical industry, outstanding client engagement and communication skills, and superior legal knowledge and acumen. This individual will work independently, interacting with the VP-Head of Intellectual Property and external counsel as dictated by the complexity, type, and sensitivity of the agreement. This position is located in Waltham, MA and reports directly to VP-Head of Intellectual Property.
Primary Responsibilities Include:
- Preparation and negotiation of agreements, including: Master service agreements (e.g., CRO), clinical trial agreements, development and manufacturing agreements, sponsored research agreements, consulting agreements, confidential disclosure agreements, material transfer agreements, and license and collaboration agreements
- Develop the contracting legal function, including:
- Identification and implementation of company-wide contracts management system
- Development of template agreements as well as alternative terms and negotiation practices
- In conjunction with the finance group, implementation of improvements to contract processes and cycle time
- Integrate the contracting function with company stakeholders, including education regarding contract policies and processes
- Provide proactive counseling to clients, including:
- Monitoring and advising on contractual rights and obligations
- Reviewing contracts to ensure compliance with legal regulations and company policies
- Advising on contract interpretation, risk management and allocation, and disputes
- Interface with the finance group on contract matters
- Provide, as needed, legal support relating to business development, compliance, and public company work
Education and Skill Requirements:
- JD from accredited law school and license to practice in at least one US jurisdiction
- 5 + years’ experience in contracts negotiation and administration in the biotech or pharmaceutical industry required with additional experience in business development, compliance, and public company work a plus.
- A dedicated, interactive, proactive, and practical individual with the ability to counsel clients at all levels of the company with clear and concise advice.
- A desire to develop and lead the contracting function and the ability to multi-task in a fast-paced environment.
Company Overview:
Dyne Therapeutics is building a leading muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. We are utilizing our proprietary FORCE™ platform to overcome the current limitations of muscle tissue delivery with modern oligonucleotide therapeutic candidates. Dyne is developing a broad portfolio of therapeutics for muscle diseases, including lead programs in myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit www.dyne-tx.com, and follow us on Twitter, LinkedIn and Facebook.
Role
Reporting to the Vice President of Accounting and Administration, this is a newly created position as Dyne begins to build out its finance team. This key leadership position within the finance department is responsible for all aspects of accounting operations, financial close, technical accounting, external reporting and internal controls including SOX 404 implementation and compliance. A successful candidate must be able to work independently in a fast-paced environment, have public company reporting experience and be willing to lead and manage a team while also rolling their sleeves up and getting into the details.
Primary Responsibilities Include:
- Direct and manage the company’s financial accounting activities in accordance with U.S. GAAP, SOX 404 and best practices in business processes.
- Develop and implement effective systems, accounting policies and financial controls which maintain the integrity of all financial transactions and reporting of the company
- Oversee and manage the external audit process and relationship with external auditors
- Oversee disbursement activities, ensuring the accurate and timely processing of accounts payable, employee expense reports and payroll
- Ensure the company maintains regulatory and U.S. GAAP compliance with all corporate income, sales and property tax requirements
- Stay abreast and informed of the latest financial and technical accounting guidance from the FASB, PCAOB and other relevant accounting bodies and ensure compliance in a timely manner
- Build, develop and manage a team of accounting professional capable of driving successful business decisions
Education and Skill Requirements:
- Minimum of a bachelor’s degree in accounting, finance, business administration or similar field is required
- CPA is highly preferable; MBA or Masters in related field is preferred
- Minimum of 8-10 years of combined Public Accounting and Private Industry accounting experience is required; Life Sciences (biotechnology, pharmaceuticals, medical device) industry experience is strongly preferred
- Strong knowledge of U.S. GAAP, SOX and external financial reporting is required
- Experience building and managing a small team of direct reports is required; proven track of forming, leading and developing high-performing teams
- Ability to work collaboratively across departmental functions and build key external relationships with auditors, lawyers, vendors, etc.
- Proficiency in Microsoft suite of programs is required
- Experience implementing and working with various systems including ERP systems, equity management systems, purchasing systems, and more
- Strong interpersonal and written and verbal communication skills including the ability to effectively communicate both clearly and concisely with all levels
- Demonstrated problem-solving and analytical skills
- Ability to manage and complete projects with time constraints
- Ability to successfully work independently and within a team environment
- Ability to maintain confidentiality of sensitive information
Company Overview:
Dyne Therapeutics is building a leading muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. We are utilizing our proprietary FORCE™ platform to overcome the current limitations of muscle tissue delivery with modern oligonucleotide therapeutic candidates. Dyne is developing a broad portfolio of therapeutics for muscle diseases, including lead programs in myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit www.dyne-tx.com, and follow us on Twitter, LinkedIn and Facebook.
Role
Dyne is seeking an experienced operational leader for the newly created A/Director of Program Management. This R&D Program Manager (PM) will work closely with the program team lead to manage multiple early stage drug development program teams as defined by the governance framework, executing the program strategy for the specific program. This person will play a key role in organizing and advancing critical R&D programs, facilitating timely and impactful decisions, and developing project, program, and portfolio strategy. This individual will have broad responsibilities to lead new research projects and to support research needs in our rapidly growing organization. This position is located in Waltham, MA and reports directly to VP-Head of Program and Alliance Management.
The ideal candidate is a highly motivated individual with exceptional communication and collaboration skills. This leadership position will afford the qualified candidate an opportunity to build and contribute to an innovative platform technology and advance Dyne's mission of pioneering life-transforming therapies for patients with serious muscle diseases.
Primary Responsibilities Include:
- Partner with program team leaders to shape the program strategy, goals, and plans and ensure alignment with senior management and broader Dyne strategy.
- Provide strategic and operational support for Dyne research, drug discovery, and early development programs
- Proactively contribute to operational project planning, risk anticipation / mitigation, team and meeting management, and coordination of decision-making. Create and maintain integrated activity plans with milestones/goals, key events, scenarios and other planning tools
- Manage program team meetings, including leading discussions to drive to effective decision-making, agenda creation, and meeting minutes
- Provide guidance to teams and line function members in negotiating challenges and driving to key decisions and milestones for programs
- Contribute to strategy reviews for Dyne research portfolio
- Partnering with Finance, support the annual goal and budget-setting process and track progress/resources throughout the year
- Contribute to and/or lead diverse initiatives to improve Dyne’s R&D operations, planning, and execution, as needed
Education and Skill Requirements:
- Ph.D., or MS with 4+ years of industry experience, or BS with 6+ years of industry experience
- Program management experience and familiarity with the drug development process from discovery to clinic
- Comfortable operating in a fast-paced cross functional environment and exerting influence and negotiating without direct authority
- Ability to constantly re-prioritize and adapt to a shifting discovery landscape – positive, persistent, flexible, and creative in the face of change
- Demonstrated leadership experience
- Excellent conflict-resolution and general people skills, ability to negotiate wide variety of personality types, highly collaborative
- Proven track record of independence, with high level of integrity, accuracy, and attention to detail
- Excellent communication skills (presentations, writing, slides, meeting facilitation)
- Ability to facilitate successful cross functional communication and collaboration in the face of complex and time-sensitive challenges
- Proficiency in Microsoft Office Suite, SharePoint, and working knowledge of project management software such as Microsoft Project, Office Timeline, One Pager, etc.
- Previous experience with regulatory filings (INDs, CTAs, etc.) with various health authorities (FDA, EMA, etc.), alliance management experience, and familiarity with rare disease field a plus
Company Overview:
Dyne Therapeutics is building a leading muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. We are utilizing our proprietary FORCE™ platform to overcome the current limitations of muscle tissue delivery with modern oligonucleotide therapeutic candidates. Dyne is developing a broad portfolio of therapeutics for muscle diseases, including lead programs in myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit www.dyne-tx.com, and follow us on Twitter, LinkedIn and Facebook.
Role
We are seeking a Director, Regulatory Affairs to help drive forward our regulatory strategy and operational activities related to Dyne’s muscle disease programs. A successful candidate must thrive working in a fast-paced environment where flexibility, accountability and fearless innovation are key. Additionally, this individual must have excellent interpersonal skills, ability to develop important relationships with key stakeholders, good conflict management and negotiation skills, ability to analyze complex issues to develop relevant and realistic regulatory and strategies. A shared passion for Dyne’s mission to bring transformative therapies to people living with serious muscle diseases is a must.
Primary Responsibilities Include:
- Interacts with other departments to develop regulatory strategy and submission plans for quality and timely filings.
- As a member of program teams, provide global regulatory guidance regarding requirements for clinical development and registration of pharmaceuticals.
- Oversee preparation, review and submission of regulatory documents maintaining compliance with regulatory requirements.
- Manage timelines and preparation of meeting requests and briefing documents.
- Author/edit documents to support regulatory submissions.
- Compile, review, approve and submit clinical trial and marketing registration applications, amendments, and supplements.
- Manage and ensure compliance with all reporting requirements, including annual and periodic reports.
- Support the organization with health authority meetings.
- Provide strategic guidance for and author applications related to expedited programs/designations for rare muscle disease (e.g. Fast Track, Orphan Drug Designation, etc).
- Manage staff and vendors as needed to support regulatory activities.
- Assist with SOP generation.
- Perform other duties as required, interfacing with other departments, CROs and external vendors as needed
Education and Skill Requirements:
- Minimum of a bachelor’s degree in life science or related discipline is required
- Minimum of 5-8 years of experience in regulatory strategy in a clinical-stage biotechnology company
- Strong experience with CTD format and content regulatory filings
- Experience and knowledge in the preparation of major regulatory submissions and supportive amendments or supplements
- Experience in Health Authority Meetings
- Knowledge of EU and international regulations related to the clinical, nonclinical, and CMC development a plus
- Ability to work independently to manage multiple projects in a fast-paced environment
- Ability to effectively collaborate effectively in a dynamic, cross-functional matrix environment to drive meeting each program’s critical regulatory milestones
- Effectively communicate the regulatory strategy, risks, mitigations, and overall plans to Project Teams and senior management
- Outstanding communication skills (verbal and written), regulatory writing skills and willingness to share knowledge and lessons learned
Company Overview:
Dyne Therapeutics is building a leading muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. We are utilizing our proprietary FORCE™ platform to overcome the current limitations of muscle tissue delivery with modern oligonucleotide therapeutic candidates. Dyne is developing a broad portfolio of therapeutics for muscle diseases, including lead programs in myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit www.dyne-tx.com, and follow us on Twitter, LinkedIn and Facebook.
Role:
Dyne is seeking a talented and highly motivated Research Associate/Senior Research Associate to join our FSHD research team. The ideal candidate will have experience with the following: mammalian cell culture (immortalized and primary cells), in vivo tissue sample processing, nucleic acid isolation for genotyping and gene expression analyses, RNA quantification (quantitative and/or digital PCR), protein quantification (Western blot and ELISA) and immunohistochemistry.
Primary Responsibilities Include:
- Design and generate data for in vitro and in vivo studies
- Analyze data and communicate findings to team members and management.
Education and Skill Requirements:
- BS/MS or equivalent in a biology, biochemistry or related discipline
- 2+ years of hands-on academic/ industry experience.
- Experience highly preferred in one or more of the following:
- Oligonucleotide therapeutics
- Antibody therapeutics
- Muscle biology
- Have excellent organizational skills, be detailed-oriented, and collaborate with others in a faced-paced environment.
- Ability to work independently and support others in a faced-paced, team-oriented environment
- Ability to effectively communicate ideas and document research data.
- Experienced in software applications (Prism, Excel, PowerPoint).