CAREERS + CULTURE

Dyne Therapeutics is a dynamic biotechnology company pioneering the discovery and development of nucleic acid medicines to treat serious rare diseases. The Company is primarily focused on rapidly advancing its muscle delivery technology and the development of its disease-modifying drug candidates.

We are seeking a talented and highly motivated Sr./ Research Associate in chemistry/biochemistry to help generate and advance our therapeutics research and support our drug discovery programs. This team member will collaborate closely with in vitro/in vivo biology colleagues to generate and characterize research materials and will also have an opportunity to help establish and contribute to the operations of our laboratories.

The successful candidate will be ambitious and energetic self-starter, be motivated to apply their skills and creativity to drug discovery and enjoy working in a fast-paced team setting. We offer a competitive salary with benefits and an opportunity for learning and advancement in an exciting start-up environment.

Responsibilities

• Execute research plans for the generation of research therapeutic candidates for in vitro/in vivo studies.
• Analyze the stability, potency and purity of therapeutic materials.
• Contribute to critical discussions of therapeutic structure, function, and new targets.

Qualifications

• BS or equivalent in chemistry or biochemistry and 2-5 years of hand on industry experience in drug discovery and development.
• Deep understanding of the principles of chemistry/biochemistry and proficiency in protein labeling techniques (e.g. NHS / Maleimide chemistry).
• Skilled in chromatographic separation (e.g. SEC, HIC, IEX, LC-MS).
• Strong organizational skills and attention to detail.
• Ability to effectively communicate ideas and document research.
• Experienced in software applications (Prism, Excel, PowerPoint).

Dyne Therapeutics is a dynamic biotechnology company pioneering the discovery and development of nucleic acid medicines to treat serious rare diseases. The Company is primarily focused on rapidly advancing its muscle delivery technology and the development of its disease-modifying drug candidates.

We are seeking a talented and highly motivated Sr./ Research Associate in cell biology to establish cell-based assays and support our drug discovery programs. This team member will collaborate closely with other in vitro/in vivo biology colleagues to develop assay strategies, establish assays using a variety of readout technologies, and execute molecular biology studies. He/She will also have an opportunity to help establish and contribute to the operations of our laboratories.

The successful candidate will be ambitious and energetic self-starter, be motivated to apply their skills and creativity to drug discovery and enjoy working in a fast-paced team setting.  We offer a competitive salary with benefits and an opportunity for learning and advancement in an exciting start-up environment.

Responsibilities

• Establish necessary cell-based assays to support drug discovery programs.
• Execute research plans for in vitro studies and support in vivo study analysis.
• Analyze data and communicate findings to team members and management.
• Contribute to critical discussion of experimental design and assay development.

Qualifications

• BS or equivalent in a biological discipline and 2-5 years of hand on industry experience in drug discovery and development.
• Experience with in vitro cell culture techniques. Experience in handling of in vivo samples is a plus.
• Experience with molecular biology techniques such as DNA and RNA extraction, qPCR, Western blot, and ELISA. Familiarity with histological protocols (tissue fixation, embedding, sectioning, staining, IF, IHC) is beneficial.
• Strong organizational skills and attention to detail.
• Ability to effectively communicate ideas and document research.
• Experienced in software applications (Prism, Excel, PowerPoint).

We are seeking a talented and highly motivated Sr./Principal Scientist to lead antibody engineering and development for our therapeutic candidates. The successful candidate will play a key role in augmenting existing antibody technologies, developing new technologies and targets, and managing relevant external collaborations.

The ideal candidate will be a collaborative team player, a clear communicator, and innovative in troubleshooting skills. S/he will be an ambitious and energetic self-starter who is motivated to apply their skills and creativity to drug discovery and enjoys working in a fast-paced team setting. We offer a competitive salary with benefits and an opportunity for learning and advancement in an exciting startup environment.

Responsibilities

• Antibody, Fc fusion protein, multi-specific antibody engineering, including implementation of humanization and affinity maturation strategies.
• Hands-on experience in determining kinetic constants, epitope mapping, and cellular receptor interactions utilizing flow cytometry and other techniques.
• Serve as a technical lead on projects in a cross-functional team setting and act as a champion for antibody development in collaboration with consultants and external CROs.

Qualifications

• PhD in immunology, molecular biology, pharmacology or related life sciences and 3-7 years of hands-on industry experience in antibody engineering and antibody/fusion protein drug development. BSc/MSc will also be considered depending on experience.
• Expertise in humanization, affinity maturation, and reformatting of antibodies is desired.
• Strong written and oral communication skills, organization and multitasking, and working in a highly collaborative and cross-functional research environment.