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Executive Director, U.S. Medical Science Liaison

Department: 122 Medical Affairs

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit, and follow us on X, LinkedIn and Facebook

Role Summary:

Medical Science Liaisons (MSLs) are the field-based extension of our Medical Affairs team. MSLs are scientifically trained professionals who possess strong clinical and/or scientific backgrounds whose role is to be a resource of balanced, impartial, and scientifically rigorous information to our patients, clinical study sites, study personnel and Key Opinion Leaders (KOLs). The Executive Director of the U.S. MSL team will be responsible for leading a team of U.S.-based MSLs that will facilitate enrollment in company sponsored studies, engage with clinical study sites, study personnel, KOLs, and other health care providers with scientific exchange and clinical support for investigational products. The MSL Team Leader will pair the changing needs of healthcare professionals with available Dyne resources. The U.S. MSL Team Leader will work under the guidance of the Global Head of Medical Affairs and in close collaboration with the Global Medical Affairs Leads (GMALs), EU Medical Affairs team, Clinical Operations, Clinical Development teams and Patient Advocacy.

This role is based in the U.S.

Primary Responsibilities Include:

  • Build, train and lead an agile U.S. MSL Team and ensure strategic alignment with all field activities globally
  • Stimulate and motivate people and teams to develop and execute medical excellence and medical leadership
  • Develop and demonstrate a thorough working knowledge of Company, investigational products, and disease state, as well as competitors and treatment landscape
  • Develop strategic and tactical KOL plans to enhance awareness of Dyne within the medical community and educate healthcare professionals on Dyne’s platform and portfolio
  • Involvement in the scientific and medical communication strategy and in any non-promotional material review as per procedure until market authorization (MA) is granted. Once the MA is granted, this person is responsible for the scientific review of any promotional material
  • Ensure the dissemination of transparent, fair-balanced medical, scientific, and clinical information, knowledge, and literature, within corporate guidelines, for healthcare provider education in a timely, compliant, ethical, and customer-focused manner
  • Ensure MSL team serves as liaison between clinical investigators and internal stakeholders in support of clinical research activities (e.g., company sponsored, investigator initiated studies)
  • Develop, maintain, and manage collaborations with regional and national KOLs, investigators, study staff (site staff and CRO staff)
  • Identify and build collaborations with KOLs for medical education and potential clinical research opportunities
  • Think strategically to translate medical/clinical insights of treatment paradigms into growth opportunities, process improvement and driving competitive advantage
  • Provide field-based medical and scientific support to answer unsolicited questions about Company, investigational products, and associated disease states
  • Deliver high quality educational presentations in a variety of settings and obtain feedback that can be disseminated throughout the organization
  • Participate in therapeutic advisory groups or Steering Committees and internal project teams, as appropriate
  • Gather and disseminate competitive intelligence from multiple sources, internally and externally
  • Attend regional / local conferences on Company’s behalf to provide feedback on current landscape, competitive landscape and continued cultivation of relationships
  • Provide feedback on specific sites and regional trends/thoughts/paradigms to identify and/or inform potential protocol amendments, accrual barriers, patient/study subject identification
  • Complete accurate and timely administrative reports, projects, and other required documentation

Education and Skills Requirements:

  • Advanced scientific degree or equivalent required (e.g., MD, PhD, RN, PharmD, MA)
  • Clinical experience within neuromuscular disorders (e.g., DMD, DM1) preferred; rare disease experience considered
  • 5+ years experience as an MSL; preferably 3+ years as an MSL team leader (regional or national)
  • Experience with relationship building and expanding a company’s reach
  • Ability to operate with ambiguity and thrive in an ever-changing environment
  • Very high level of learning agility and communication skills encompassing:
    • Strong comprehension of investigational products and a solid understanding of the neuromuscular space, including new data as it becomes available
    • Ability to cultivate and maintain relationships with national, regional, and local KOLs to establish trust through the consistent demonstration of scientific expertise and satisfactory follow-through to requests from thought-leaders
    • Professional communications (written, verbal, presentation, and listening) to cultivate and nurture strong working relationships with internal and external colleagues
  • Demonstrated ability to work effectively on multi-disciplinary teams in order to achieve desired outcomes
  • Demonstrated understanding of pharmaceutical industry practices, as well as standard medical practices in therapeutic area(s) of concentration and broad therapeutic competency (e.g., keeps current with new information and trends in the field)
  • Ability to work independently, within a home office while efficiently managing a team, including the team’s time and priorities
  • Must conduct oneself in a highly professional and ethical manner;
  • Demonstrated ability to liaise with CRO, Company Clin Ops, and Study Medical Monitor to provide site recommendations based on prior knowledge of territory/investigators/allied health; participate in SIVs
  • Ability to leverage past relationships in neuromuscular disorders to ensure interest and commitment from sites/investigators for study enrollment and open communication re: feedback to Company
  • Must be willing to travel extensively and occasionally on weekends

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.