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Senior Scientist, Oligonucleotide Chemistry

Department: 103 Platform

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook

Role Summary:

As a member of the Platform Oligo innovation team, the successful candidate will contribute to the development of Dyne’s oligonucleotide chemistry platform and enable the discovery of novel oligonucleotide therapeutics. This individual will be responsible for building an internal oligonucleotide chemistry lab and will lead the design, synthesis, purification, and analysis of oligonucleotides and their conjugates. The position requires a combination of deep technical expertise in oligonucleotide synthesis and in-depth knowledge of oligonucleotides as a therapeutic modality.

This role is based in Waltham, MA without the possibility of being a remote role. Applicants must be able to relocate to the area.

Primary Responsibilities Include:

  • Independently perform solid phase synthesis of oligonucleotides with diverse sugar and backbone modifications at various scales
  • Troubleshoot and optimize synthesis methods to produce high quality oligonucleotides of various lengths
  • Perform purification (anion exchange, reverse phase), analysis (HPLC/UPLC), characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates
  • Explore novel chemistries and designs to improve the DMPK and safety properties of oligonucleotides
  • Manage hit-to-lead optimization process and deliverables
  • Interact with the biology and preclinical groups to deliver clinical candidates
  • Multi-task across several projects and manage time effectively to achieve results
  • Collect, present, and discuss data at internal team meetings

Education and Skills Requirements:

  • PhD in chemistry or related discipline with a minimum of 4 years of experience in oligonucleotide synthesis -prior postdoctoral experience is preferred- or MSc with at least 7 years of industrial experience in the biotechnology industry
  • Strong experience with the operation of oligonucleotide synthesis machinery (Mermade), and AKTA purification unit
  • Working knowledge of RNA biology to enable collaboration across functions
  • Experience with ASO, siRNA or other DNA/RNA targeting modalities
  • Experience in nucleoside chemistry and bioconjugation are a plus

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The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.


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