Our commitment to people with muscle diseases
is our greatest strength

Senior Research Associate, Mechanistic Biology

Department: 102 Biology

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

The Senior Research Associate will be part of the Mechanistic Biology team and will support the DM1 program, collaborating closely with cross-functional groups to execute biological assays using a variety of readout technologies.

The successful candidate will be an ambitious, motivated, energetic self-starter who enjoys working in a collaborative and fast-paced laboratory setting. 

Primary Responsibilities Include:

  • Contribute to in vitro and in vivo IND-enabling studies to characterize mechanism of action and PK/PD profiles of therapeutic candidates in relevant disease models
  • Contribute, intellectually and technically, to development of new assays aimed at answering key muscle disease questions to facilitate the programs successful transition to the clinic
  • Execute assays to drive optimization of the FORCE™ platform
  • Communicate findings to team members and management
  • Contribute to building a positive culture of teamwork and scientific excellence
  • Document research efforts and maintain proper records

Education and Skills Requirements:

  • BS/MS or equivalent in a relevant biological discipline and 1-3 years of hands-on biotech/biopharma or academic
  • Extensive experience conducting in vivo studies with small rodents including:
    • Dosing by several routes of administration
    • Tissue collection and processing for downstream assays
  • Proficiency with standard histological protocols such as tissue-fixation, embedding, sectioning, immunofluorescence, immunohistochemistry, and in situ hybridization are desirable
  • Hands on experience with molecular biology techniques including:
    • Nucleic acid extraction and gene expression analysis by qPCR or digital PCR
    • Western blots and ELISA
  • Ability to communicate ideas and document research effectively and clearly
  • Highly organized and collaborative nature
  • Experienced in the use of software applications such as Prism, Excel, PowerPoint, and SnapGene (or equivalent).

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.


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