Skip to main content
Our commitment to people with muscle diseases
is our greatest strength
We support all people, families and caregivers living with rare diseases, this Rare Disease Day and every day

Scientist, Platform Discovery

Department: 103 Platform

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook

Role Summary:

As a member of the Platform Discovery team, the successful candidate will contribute to the development of new therapies for serious muscle diseases. The scientist will collaborate closely with early research and program teams to support the discovery and characterization of new targets and therapeutics. The successful candidate will provide scientific leadership, bring innovative ideas to solve complex problems, and communicate effectively within and across functions to advance research activities.

This role is lab focused, based in Waltham, MA without the possibility of being remote. Applicants must be able to relocate to the area.

Key Responsibilities include:

  • Independently design, execute, and report biochemical and cellular assays for characterizing novel drug candidates, and their impact on muscle biology
  • Develop new assays to address mechanistic questions related to our delivery platforms
  • Utilize public and proprietary resources to explore and validate novel targets and targeting modalities for pipeline expansion opportunities
  • Work effectively and collaboratively with other functions including Neuromuscular Research, Preclinical Development, and Data Sciences to collectively advance R&D activities
  • Contribute to critical discussions of therapeutic structure, activity, and function
  • Contribute to additional Platform expansion activities
  • Present data to internal and external audiences via talks, abstracts, posters, and original manuscripts

 Education and Skills Requirements:

  • PhD in biology, biochemistry, or a similar field, or MSc with 3-5 years of equivalent hands-on industry experience in early drug discovery
  • Experience with mammalian cell culture and established molecular and biochemical techniques including flow cytometry, fluorescence microscopy, cell reporter systems, cloning, qPCR, western blot, and ELISA
  • Experience developing assays to elucidate mechanistic pathways
  • Experience with antibodies, antibody conjugates, or other biologics is desired
  • Ability and motivation to rapidly learn and apply new technologies
  • Strong written and oral communication skills and working in a highly collaborative and cross-functional research environment.
  • Strong organizational skills, multitasking, attention to details, and ability to effectively document research
  • Experienced in software applications (Prism, Excel, PowerPoint, Electronic notebooks)

#LI-Onsite

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.


BACK | NEXT