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Our commitment to people with muscle diseases
is our greatest strength

Scientist, Platform Discovery

Department: 103 Platform

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne has a broad portfolio of programs for serious muscle diseases, including candidates for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

Dyne is seeking a Scientist – Platform Discovery. The Scientist – Platform Discovery will collaborate closely with early research and program teams to support the discovery and characterization of new targets and therapies.  The successful candidate will bring innovative ideas to solve complex problems and communicate effectively within and across functions to advance research activities.

This role is based in Waltham, Massachusetts, without the possibility of being a remote role. 

Primary Responsibilities Include:

  • Develop, optimize and execute in vitro assays for screening, characterization and optimization of novel drug candidates
  • Analyze the potency, efficacy and potential safety lability of therapeutic materials
  • Study the impact of new drug candidates on muscle biology and signaling pathways
  • Explore and validate novel targets to expand our FORCE platform
  • Contribute to critical discussions of therapeutic structure, activity, and function
  • Present data to internal and external audiences via talks, abstracts, posters, and original manuscripts

Knowledge & Skill Requirements:

  • A PhD in biology, biochemistry, or a similar field with at least 2 years of hands-on industry experience in early drug discovery, or equivalent academia experience
  • Experience with mammalian cell culture and in vitro cell-based assays (Flow Cytometry, Fluorescence Microscopy, FRET/BRET, cell reporter systems)
  • Experience with biochemical and pharmacological assays (Western blot, ELISA)
  • Experience in molecular biology (cloning, qPCR)
  • Experience characterizing signaling pathways and deciphering mechanism of actions of therapeutic material
  • Ability and motivation to rapidly learn and apply new technologies
  • Knowledge of muscle biology is desired but not a must
  • Strong organizational skills and attention to details
  • Ability to effectively communicate ideas and document research
  • Experienced in software applications (Prism, Excel, PowerPoint, ELN)


The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.