Scientist, Platform Discovery

Our commitment to people with muscle diseases

is our greatest strength

Scientist, Platform Discovery

Department: 103 Platform

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on Twitter, LinkedIn and Facebook.

Role Summary:

Dyne is seeking a talented in-vitro biologist to join the FORCE TM Platform Discovery team. This is an exciting opportunity for a highly motivated scientist interested in further developing their career in industry, while impacting Dyne’s efforts to develop new therapies for muscle genetic diseases. This individual will establish and utilize cell-based assays to support early discovery screening efforts through in vitro proof-of-concept and lead selection. The scientist will work with reporter cell lines, perform various cellular assays by Flow Cytometry/Microscopy, evaluate gene expression and characterize novel drug candidates by Surface Plasmon Resonance. The candidate will join a group of scientists working in a cross-functional setting.

Exceptional communication and collaboration skills are required. The qualified candidate will have the opportunity to build, contribute to, and expand our novel FORCETM platform technology to advance Dyne's mission of pioneering life-transforming therapies for patients with serious muscle diseases.

Primary Responsibilities Include:

Develop, optimize and execute in vitro assays for medium to high-throughput screening of novel drug candidates
Analyze the stability, potency and efficacy of therapeutic candidates
Identify and validate novel tissue specific receptor targets to expand our FORCE platform
Contribute to comparative analysis of structure, activity, and function of lead candidates

Knowledge & Skills

PhD in biology, biochemistry, or a similar field with at least 2 years of hands-on industry experience in early drug discovery, or MS with 4 years of similar experience
Experience with cell culture and in vitro cell-based assays (Flow Cytometry, Fluorescence Microscopy, ELISA, cell reporter systems, RT-PCR)
Ability and motivation to rapidly learn and apply new technologies
Experience with biologics, nucleic acid therapeutics, antibody-drug-conjugates (ADCs) or antibody labeling is a plus
Strong organizational skills and attention to details
Ability to effectively communicate ideas and present data
Experienced in software applications (Prism, Excel, PowerPoint, ELN)
Must be authorized to work in the United States
Position is based in Waltham, MA; no relocation package available

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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