Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on Twitter, LinkedIn and Facebook.
Dyne Therapeutics is seeking a candidate that will perform synthesis and purification of modified oligonucleotides (ASO, siRNA) for our drug discovery programs. S/He will be reporting to the Director of Oligonucleotide Chemistry. Successful candidates will have significant experience with solid phase chemical synthesis, conjugation, HPLC purification, and LC-MS analysis, preferably with oligonucleotides. Expertise operating LCMS and HPLC is required; experience using oligonucleotide synthesis equipment is preferred.
S/He will collaborate closely with additional chemistry, biology, and research teams, supporting various stages of preclinical therapeutic development. S/He will work in a collaborative, constructive and mission-oriented focus for improving the lives of patients.
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.