Our commitment to people with muscle diseases
is our greatest strength

Scientist, Neuromuscular Research

Department: 102 Biology

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

The Scientist in Neuromuscular Research is critical in developing new therapies for genetic neuromuscular diseases. This role is involved in all aspects of in vitro and in vivo disease biology; evaluating efficacy, pharmacodynamics, pharmacokinetics, and mechanisms of action of our therapeutic molecules. This role leads from the bench and conducts the development and implementation of patient cell and animal disease models that support ongoing projects. As part of the Dyne research team, this individual is an innovative and collaborative team player who enjoys working in a fast-paced team setting.

This role is based in Waltham, MA without the possibility of being a remote role. Applicants must be able to relocate to the area.

Primary Responsibilities Include:

  • Design, execute, and analyze in vitro and in vivo studies to profile candidates for proof of mechanism and proof of concept
  • Evaluate and validate neuromuscular disease models
  • Utilize creativity and resources to design, evaluate, and develop new assays to answer key scientific questions to drive programs towards clinical development
  • Contribute to the strategy and tactics of multiple cross-functional projects.
  • Work effectively with other disciplines including Platform Development, Platform Pharmacology, and Preclinical Development to collectively build the preclinical data package to support clinical development
  • Contribute to building a positive, team-oriented culture

Education and Skill Requirements:

  • PhD in molecular biology, pharmacology or related life sciences and 2+ years of hands-on post-doctoral experience or BSc/MSc with 5+ years of relevant industry experience is required
  • Experience in providing scientific and technical leadership applied to novel assay development, advancing challenging drug discovery programs, and mentoring junior colleagues
  • Strong hands-on experience working with disease models including primary cell culture and rodent models
  • Experience with established molecular techniques including qPCR, western blotting, ELISA, immunohistochemistry/immunofluorescence, fluorescence in-situ hybridization, flow cytometry, and confocal microscopy
  • Strong written and oral communication skills, organization, and multitasking, and working in a highly collaborative and cross-functional research environment
  • Proven ability to work independently and effectively manage CROs and to facilitate interactions with academic labs to ensure project progression is desirable
  • Strong track record of scientific accomplishments with relevant publications and presentations

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.


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