Our commitment to people with muscle diseases
is our greatest strength

Research Associate, Platform Development

Department: 103 Platform

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

Dyne is seeking a talented and highly motivated Research Associate in biology, chemistry, or biochemistry to help generate and advance our therapeutic research and support drug discovery programs. S/He will join a team of scientists and collaborate in a cross-functional setting, to develop and characterize research grade materials for in vitro/in vivo studies. The successful candidate will have experience working with biologics, nucleic acid therapeutics and competent in various chromatography techniques.

Exceptional communication and collaboration skills are required.  The qualified candidate will be a self-starter and motivated to apply their skills and creativity in a drug discovery setting.  S/He will have the opportunity to build, contribute to, and expand our novel platform technology and advance Dyne's mission of pioneering life-transforming therapies for patients with serious muscle diseases.

This role is based in Waltham, Massachusetts without the possibility of being a remote role. 

Primary Responsibilities Include:

  • Design, optimize and execute biological conjugations with multiple proteins and payloads ranging from milligram to gram scale
  • Utilize AKTA systems to perform purifications on raw materials and conjugates
  • Perform biochemical analysis on in-process and final purified conjugates- including the following techniques- Mass Spectrometry (LC-MS), CE-IEF, CE-SDS, SDS-PAGE, BCA, HPLC/UPLC, and UV-vis
  • Perform Tangential Flow Filtration (TFF; UF/DF) from the milliliter to multi-Liter scale
  • Write technical reports to support technical transfers
  • Contribute to critical discussions of therapeutic structure, function, and new targets across all company levels
  • Maintain an electronic lab notebook in a timely manner

Education & Skill Requirements

  • BS or equivalent in biology, chemistry or biochemistry and 2-3 years of experience in drug discovery and development or MS in biology, chemistry or biochemistry with coursework or research in drug discovery and development
  • Demonstrated understanding of the principles of chemistry/biochemistry
  • Broad experience in antibody-payload conjugation, purification and characterization is a plus
  • Strong organizational skills and attention to detail
  • Ability to effectively communicate ideas and document research
  • Experienced in software applications (Prism, Excel, PowerPoint)
  •  

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.


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