Research Associate, Neuromuscular Research
Department: 102 BiologyLocation: Waltham, MA
Company Overview:
Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne has a broad portfolio of programs for serious muscle diseases, including candidates for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on Twitter, LinkedIn and Facebook.
Role Summary
Dyne is seeking a highly motivated Research Associate in the Neuromuscular Research team based in Waltham, MA. This team member will support the FSHD program and collaborate closely with cross-functional groups to execute biological assays using a variety of readout technologies. The successful candidate will be an ambitious, motivated, energetic self-starter who enjoys working in a collaborative and fast-paced laboratory setting.
Primary Responsibilities Include:
- Provide technical support to in vitro and in vivo IND-enabling studies aimed at characterizing mechanisms of action and PK/PD profile of therapeutic candidates in relevant biological systems
- Support development of new assays to answer key muscle disease questions to ensure programs successfully progress the clinic
- Execute assays to drive optimization of the FORCE™ platform
- Communicate findings to team members and management
- Contribute to building a positive culture of teamwork and scientific excellence
- Document research efforts and maintain proper records
Education and Skill Requirements
- BS or equivalent in a biological discipline and 1-3 years of hands-on biotech/biopharma or academic experience
- Experience conducting in vivo studies with small rodents, including:
- Dosing by several routes of administration
- Tissue collection and processing for downstream assays
- Proficiency with molecular biology techniques including:
- Nucleic acid extraction and gene expression analysis by qPCR or digital PCR
- Western blots and ELISA
- Hands-on experience with standard histological protocols such as tissue-fixation, embedding, sectioning, immunofluorescence, immunohistochemistry, and in situ hybridization would be desirable
- Excellent organizational skills and ability to work in a team
- Ability to effectively communicate ideas and document research
- Experienced in the use of software applications such as Prism, Excel, and PowerPoint
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The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
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