Our commitment to people with muscle diseases
is our greatest strength
On World FSHD Day and every day, Dyne is dedicated to making a difference by advancing potentially life-transforming therapies for individuals and families living with FSHD.

VP, Program Team Leader

Department: 201 CEO

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

The Program Team Leader (PTL) will provide strategic leadership and development acumen and, as part of the company’s leadership team, will contribute to company vision for developing therapeutics for patients with serious muscle diseases. They will be responsible and accountable for overall leadership of a high-performing cross-functional team developing a transformational medicine for patients in need.  Working closely with an experienced Program Manager, the PTL will guide the establishment of an aligned strategic vision for the asset, near-term goals that further this vision, and an integrated plan to successfully advance the program through development and to market.  As a visionary leader with an entrepreneurial style, they will have passion to create opportunities, solve problems and successfully drive complex projects. They will bring a ‘future-orientation’, thinking always about the ultimate goal of broad, global commercial access for patients in need.  Their influencing and engagement skills will allow them to build a highly motivated team and manage key stakeholders, including members of the executive leadership.

The right individual will be passionate about developing and commercializing life-transforming therapies for patients with severe and life-threatening muscle diseases and will develop strong knowledge of the Dyne programs (scientific and clinical data, patient population, market environment, global payor landscape, etc.). The PTL will be adept at operating in and building strong teams, developing effective cross-functional relationships and being able to work in a fast-paced, patient-focused environment. 

This role is located in Waltham, MA without the possibility of being remote.

Primary Responsibilities Include:

  • Lead a high performing cross-functional team, with focus on both the “what”, such as priorities, output, and resources, and also the “how” of maintaining a fulfilling, collaborative, and sustainable team environment
  • Establish an aligned Program vision and strategy for bringing a life-changing medicine to patients in need, clearly understood and enthusiastically supported by team members and broader Dyne leadership
  • Sponsor the creation of the target product profile (TPP) in collaboration with new product planning and cross-functional representatives and in alignment with company leadership
  • Ensure that non-clinical, clinical, regulatory, and commercial strategies and plans are aligned with the TPP and the overall Program Strategy
  • Oversee development of an efficient operational plan to deliver on strategy, optimizing for quality, speed and cost
  • Assume ownership of program recommendations across stages of the program to achieve milestones and timelines
  • Maintain clear and open communication with Dyne Senior Leadership and other stakeholders regarding program status, priorities, risks and needs, and facilitate appropriate strategic decision-making
  • Keeps abreast of emerging developments regarding research and development in the fields of muscle diseases and oligonucleotide drug discovery and development
  • Build visible, constructive, and credible presence within KOL and patient community for relevant disease area
  • Participate in business development activities, including opportunity evaluations and due diligence
  • Provide motivating leadership example within Dyne more broadly during period of rapid growth, typifying Dyne's “One Team, No Ego” leadership orientation
  • Responsibly steward the program budget in collaboration with finance
  • Foster a culture of collaboration, innovation, discovery, and cutting-edge research culture focused on scientific excellence, open communication, and continual improvement
  • Consider needs of Program in context of Dyne corporate strategy and priorities, as primary advocate for Program among Dyne senior leadership

 Knowledge & Skills

  • Proven and respected leader with:
    • Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent
    • 12+ years of experience in pharmaceutical industry in leadership positions in drug development and proven track record in driving programs through IND, early clinical, pivotal stages and approval
    • Experience in rare genetic diseases preferred
    • And/or at least 12 years in pharmaceutical industry in significant commercial leadership or general management positions including working with development and manufacturing teams in cross-functional setting, with exceptional track record of delivering on business objectives, activity/milestones leading to filing and launching, and, with strong knowledge in the therapeutic area
  • Proven acumen for cross-functional leadership and influencing without direct authority
  • Demonstrated experience in building highly effective teams and guiding teams and organizations in making complex and high-stakes data-driven decisions
  • Proven ability to establish and maintain credible and trust-based relationships with external stakeholders (e.g., KOLs, patient advocacy groups, regulators or investors)
  • Outstanding sense of urgency and ability to pace the team’s work to achieve milestone achievement in highly competitive environment
  • Excellent communication skills (verbal, written, presentation) and ability to communicate well with all stakeholders and teams
  • Natural focus on team dynamics and proven ability to coach and support team members to perform at their best
  • Orientation towards collective achievement and team credit, combined with individual sense of responsibility and accountability for teamwork and product
  • Comfort with ambiguity and ability to provide steadiness and consistency in environment of shifting priorities, demands and timelines
  • Effective people-oriented collaboration skills in an environment with cross functional teams, contractors, resources, and third-party vendors
  • Ability to manage and lead by influence complex projects with ambitious milestones in a cross-functional team environment and high-pressure circumstances
  • Comfortable in a results-driven, highly accountable environment where you can make a clear impact
  • Team player and mentor, who listens effectively and invites response and discussion A collaborator who communicates in an open, clear, complete, timely and consistent manner
  • Experience in Phase I-III drug development is required

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.


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