Our commitment to people with muscle diseases
is our greatest strength

Principal Scientist, Bioinformatics – Data Sciences

Department: 106 Data Sciences

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

Dyne is seeking an experienced Bioinformatics Data Scientist with a proven track record in applying up-to-date computational methods to drive drug discovery and development.  Reporting to the Vice President, Head of Data Sciences, the successful candidate will design and execute bioinformatics methodologies focused on accelerating our R&D programs and advancing our FORCE™ platform. 

This role offers an exciting opportunity to work alongside biologists and platform scientists to discover and advance innovative therapeutic candidates to the clinic.  You will apply your expertise in computational analytics to extract insights from integrated genetics, ‘omics and other data sets.  As a computational SME, you will help build a new data science capability that will support data-driven decision-making across R&D programs.  You will be a key contributor to developing and implementing scientific strategy to drive the development of our next generation delivery technologies and identify new therapeutic opportunities. 

This role is based in Waltham, MA without the possibility of being a remote role. Applicants must be able to relocate to the area.

Primary Responsibilities Include:

  • Developing computational methods for analysis and integration of genetic and ‘omics data for target and biomarker discovery
  • Identifying, ingesting, and integrating key external and internal data sets to advance understanding of neuromuscular disease biology and potential therapeutic strategies
  • Establishing bioinformatics analysis workflows to support oligonucleotide therapeutic design, selection, and prioritization
  • Working closely with our DM1, DMD and FSHD teams to support our clinical programs in advancing our next generation of development candidates
  • Partnering with our Platform Development and other Research functions to contribute to the evolution of our FORCE™ platform and the identification and validation of new therapeutic opportunities
  • Working with external consultants and scientific collaborators to deliver fit-for-purpose bioinformatics solutions
  • Contributing to the preparation of abstracts, posters, and papers for internal and external presentation
  • Delivering high-quality analytical results and scientific excellence while fostering a culture of teamwork, transparency, and accountability

 Education and Skills Requirements:

  • PhD in bioinformatics, computational biology, applied mathematics or equivalent discipline with a minimum of 5 years of relevant industry experience
  • Hands-on proficiency with a broad range of current bioinformatics and computational biology tools, methods, and applications
  • Expert coding ability in R and/or python with application to ‘omics data analysis and visualization
  • Facility with computing frameworks for analytics automation and data processing pipelines
  • Strong background in statistical methodology, predictive analytics, and concepts underlying machine learning in high-dimensional data
  • Demonstrated ability to partner with bench scientists for design of innovative experiments and interpretation of key results
  • Exceptional ability to communicate complex analytical and technical concepts to diverse audiences through verbal, visual, and written media
  • Experience operating in a cloud-based high-performance computing environment, including virtual systems, distributed processes, and data storage management
  • Thrives in a fast-paced, highly collaborative environment, with ability to act independently and adapt to changing priorities

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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