Our commitment to people with muscle diseases
is our greatest strength

Principal Scientist, Bioanalytical ADME

Department: 102 Biology

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

We are seeking an experienced and highly innovative bioanalytical scientist to join Dyne’s Bioanalytical ADME Team. Leverage your hands-on scientific and technical background with the detection and quantification of oligonucleotides you will play a leading role in the design, analysis, interpretation, and reporting of bioanalytical data from preclinical pharmacology, pharmacokinetic, and safety/toxicology studies.

This position offers the opportunity to work broadly across Dyne’s pipeline and functions, and to interface with external vendors and partners.  The individual in this role will be a proactive scientist who thrives in a dynamic environment with a high degree of self-drive and autonomy. 

This role is based in Waltham, MA without the possibility of being a remote role.

Primary Responsibilities Include:

  • Lead method development and implementation of fit for purpose bioanalytical assays using state of the art methodologies (i.e., ELISA and LC-MS/MS) to gain a deep understanding of the pharmacokinetic attributes of our therapeutic molecules and to advance our oligonucleotide delivery platform
  • Optimize and run sample preparation methods for blood, urine and solid tissues
  • Generate key data that support novel Development Candidates nomination, IND fillings, and build next generation drug delivery solutions
  • Analyze, interpret and report key findings to enable Program Team decision making, publication and patents
  • Implement laboratory automation and miniaturization strategies to increase throughput and expedite timelines
  • Identify CRO partners and subsequently oversee outsourced work
  • Contribute towards building our Bioanalysis Team
  • Work closely with Leadership and Program Teams to ensure alignment of activities and management of timelines and deliverables
  • Foster a positive culture of teamwork and scientific excellence
  • Accountable for proper documentation of internal and external research efforts

Education and Skills Requirements:

  • Advanced degree in Analytical Chemistry, Pharmaceutical Sciences, Pharmacokinetics or equivalent with a minimum of either 5 years (with PhD) or 10 years (with BSc) of relevant industry experience
  • Knowledge of current and cutting-edge bioanalytical approaches used to detect and quantify oligonucleotides including ELISA and LC-MS/MS based approaches
  • Proven track record of developing and applying bioanalytical assays that support the identification and development of oligonucleotide-based therapeutics
  • Exceptional organizational and communication skills, ability to work cross-functionally and with a strong background in directing work at external CROs
  • Ability to work independently and manage multiple shifting priorities
  • Strong track record of research accomplishments with relevant publications, presentations, and/or patents
  • High proficiency in the use of software applications such as Prism, Excel, and PowerPoint
  • Additional experience with antibody-drug conjugates, expertise with WinNonlin and proficiency with in vivo dosing and sample collection are highly desirable

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.


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