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Preclinical Development Co-Op

Department: 104 Non-Clinical

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit, and follow us on X, LinkedIn and Facebook

Role Summary:

Dyne’s Co-Op Program offers students the opportunity to gain expertise in a variety of core laboratory skills and work in a dynamic biotech environment equipped with state-of-the-art technology. This is an exceptional opportunity for an independent and highly motivated graduate student to actively contribute towards advancing our novel muscle disease programs and to collaborate with other functional groups. Students will receive support from experts to learn industry standard best practices for the design, execution, interpretation, and presentation of experiments that drive key drug discovery decisions..

The student will work closely with mentor(s) to conduct bioanalytical assays to understand disposition of our platform tested in various in vitro/in vivo models. There will also be opportunities to train cross-functionally with other scientists within the company. The successful candidate will be team-oriented, ambitious, motivated, and enjoy working in a fast-paced environment.

This is an onsite 6 month, temporary position beginning in July 2024. Students must be local or able to relocate

Primary Responsibilities Include:

  • Support research plans to analyze in vitro/in vivo studies with various bioanalytical methods including LC-MS and ELISA, as well as qPCR
  • Participate in literature research to investigate new technologies, experimental design, and method development for bioanalytical assays
  • Participate in the design and execution of studies to understand the absorption, metabolism, distribution, and excretion (ADME) of drug candidates
  • Maintain accurate and clear records of experimental work
  • Work effectively with cross-functional teams to deliver high-quality results
  • Analyze data and communicate findings to team members
  • Follow general laboratory safety procedures, as related to biologically derived materials
  • Present research findings at departmental and company-wide meetings

Education and Skills Requirements:

  • Working toward a M.S. or Ph.D. degree in Chemistry, Biology, Pharmaceutical Sciences, or equivalent
  • Previous hands-on experience and knowledge of mass spectrometry is desired
  • Self-motivated and possess the ability to effectively communicate ideas, analyze experiment results, and document research
  • Familiar with creating PowerPoint presentations and scientific posters



The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.