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Neuromuscular Biology Co-Op

Department: 102 Biology

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne has a broad portfolio of programs for serious muscle diseases, including candidates for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit, and follow us on TwitterLinkedIn and Facebook.

Role Summary

We seek a highly motivated Co-Op Student to join the Neuromuscular Biology team to execute established biomarker assays using a variety of readout technologies. The student will work closely with mentor(s) to conduct high-throughput experiments using robotics to understand the mechanism of action of drugs tested in cellular and animal models. There will also be opportunities to train cross-functionally with other scientists within the company. The successful candidate will be team-oriented, ambitious, motivated, and enjoy working in a fast-paced environment.

This role is based in Waltham, MA without the possibility of being a remote role. This role will be for a 6 month period beginning in January 2023.

Key Responsibilities of the Role:

  • The individual will support research plans to analyze research studies with biochemical and histological readouts for target engagement, mechanism of action, and therapeutic efficacy
  • Support biomarker assays to isolate nucleic acids and proteins
  • Perform qRT-PCR and protein-based assays to look at gene and protein expression in tissues
  • Participate in literature search, experimental design, and optimization of molecular biology assays
  • Maintain accurate and clear records of experimental work
  • At the end of the program, you will present a summary of the project to the department


Education and Experience Requirements:

  • Self-motivated junior/senior undergraduate with a background in Biology, Biotechnology,

Pharmacology or an equivalent in a biological discipline

  • Previous hands-on academic/ industry experience with molecular biology techniques is desired including, but not limited to
    • Handling in vivo samples
    • Nucleic acid isolation extraction for gene expression analysis
    • Protein isolation
  • The candidate must be self-motivated and possess the ability to effectively communicate ideas and document research.



The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.