Our commitment to people with muscle diseases
is our greatest strength

Director, Oligonucleotide Synthesis

Department: 103 Platform

Location: Waltham, MA

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

The Director of Oligonucleotide Synthesis will report to the Head of Platform Development and is responsible for leading oligo design, manufacturing and purification at Dyne.  S/he will manage internal and external oligo synthesis, analytics, and characterization of ASO and siRNA chemistries.  Candidate will be a subject matter expert in the understanding of testing, scale-up and cGMP manufacturing of nucleic acid drugs with a comprehensive understanding of oligo delivery and formulations.  S/he will collaborate closely with additional chemistry, biology, and research teams, supporting all stages of preclinical therapeutic development.  Candidate will use creative and proactive problem-solving strategies to progress oligo design and development in support of Dyne’s therapeutic pipeline.  S/he will act as an effective technical expert and work in a collaborative, constructive and mission-oriented focus for improving the lives of patients.

Education and Skills Requirements:

  • PhD in Chemistry, Biochemistry, or related discipline; with 8-10 years of relevant experience in drug discovery and development.
  • Strong practical knowledge of design, synthesis, and purification of nucleic acids.
  • Experience in scale-up manufacturing.
  • Excellent project, time management, and problem-solving skills.
  • Proven leadership and interpersonal skills, including ability to work across functional lines.
  • Ability to select and manage third-party vendors and collaborators, communicate technical information and work with all levels and functions within the Company.
  • Excellent written and verbal communication skills, including making effective and compelling presentations in both large and small groups and communicating complex scientific and nonscientific issues to program teams.
  • Ability to critically evaluate, summarize, interpret data.
  • Understand published scientific literature outside of his/her immediate area of expertise and appropriately apply this understanding to company aspects
  • Prepare manuscripts and other documents for publication and/or regulatory submission


The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.