Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com/, and follow us on Twitter, LinkedIn and Facebook.
The Director, Oligonucleotide CMC and External Manufacturing will be responsible for building our internal CMC capability (antibody process & analytical development) and for the management of external specialist Oligonucleotide CDMOs under cGMP. Areas include oligonucleotide process and analytical development, drug substance and drug product from pre-IND through late-phase clinical studies. The incumbent will be responsible for the delivery of robust, scalable, and cost-effective manufacturing. This individual will manage our external CDMO’s to ensure that all supply partners are in compliance with appropriate global regulatory standards. In addition, the position will provide leadership defining the company’s overall CMC strategy within a matrixed environment.
This role is based in Waltham, MA without the possibility of being a remote role.
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.